Cytonex Stem Cell & Exosome Research
Advancing Regenerative Science Through
Rigorous Discovery
Research & Innovation
Science in Progress
Cytonex’s R&D programme advances Mesenchymal Stem Cells (MSC) and MSC-derived Extracellular Vesicles (EV) therapeutic potential — translating cutting-edge regenerative science into next-generation health solutions.
BioNexus Status
Company
Combined R&D
Experience
Compliant
Laboratory
Exosomes Purity
Featured Research
Our Latest R&D Findings
Cytonex’s active research pipeline — exploring the safety, efficacy, and novel characterisation
of MSC-derived extracellular vesicles.
Assessment of Safety, Cellular Uptake and
Anti-Inflammatory Efficacy of MSC-Derived Extracellular Vesicles in COPD-Related Wound Healing Using Primary Human Airway Cells
Evaluating the safety, cellular uptake, and anti-inflammatory effects of MSC-derived extracellular vesicles using primary human airway cells.
A Novel Surface-Enhanced Raman Scattering (SERS) Spectral Identification and Characterization of Wharton's Jelly MSC-derived Extracellular Vesicles
Developing advanced spectral technology to identify and characterise extracellular vesicles derived from Wharton’s Jelly mesenchymal stem cells.
Research Pipelines
Ongoing R&D Programmes
A continuously expanding research portfolio pushing the boundaries of MSC and MSC-exosomes based therapies and products — from advanced wound care to minimally invasive delivery systems.
MSC-exosome in
Large Wound Treatment
Investigating MSC-derived exosomes efficacy and therapeutics in improving healing in large and chronic wounds.
MSC-exosome
Microneedling
Exploring the effectiveness and safety of combining microneedling technology with regenerative exosome treatments.
Advanced Patented Exosome Isolation & Purification
Developing patented techniques to improve exosome purity, stability, and production yield.
INTELECTUAL PROPERTY
Our Patented Technology
A continuously expanding research portfolio pushing the boundaries of MSC and MSC-exosomes based therapies and products — from advanced wound care to minimally invasive delivery systems.
Patented Stem Cell Conditioned Media & Isolation Technique
Significantly improves MSC-derived exosome yield and purity — enabling consistent, high-potency therapeutic preparations for downstream clinical and cosmetic applications
Our Patent-Pending Technology
An exosome-based inhalation and its delivery system for the treatment of chronic obstructive pulmonary diseases and a method of isolating exosome from umbilical cord-derived mesenchymal stem cells
Inhalable formulation from MSC-derived EVs and it's delivery methods to the lung using nebulizer
Scientific Publications
Published Works
Research originating from our laboratory and R&D programme
The antioxidant properties and microbial load of Moringa oleifera leaves dried using a prototype convective air-dryer
Low-cost convective-air dryer preserves Moringa leaf antioxidants, reduces microbes, and reveals bioactive compounds—promising sustainable preservation and sanitizer potential.
Antiproliferative effects of dried Moringa oleifera leaf extract on human Wharton’s Jelly mesenchymal stem cells
This study is the first to investigate the cytotoxicity of a highly valued medicinal plant, Moringa oleifera, on human Wharton’s Jelly mesenchymal stem cells (hWJMSCs) and its effects on the cells’ gene expression when used as a pre-treatment agent in vitro.
A Review of Surface-Enhanced Raman Scattering (SERS) for the Characterisation of Extracellular Vesicles
This paper is beneficial as a comprehensive review of Extracellular Vesicles (EVs) analysis, which addresses the growing importance of EVs and highlights SERS as a promising, non-invasive, superior sensitivity to conventional Raman and other characterisation methods.
An Optimized Serum and Xeno-Free Expansion Protocol for Wharton's Jelly- derived Mesenchymal Stem Cells as a Clinically Compliant Alternative for Serum-Based Culture
This study presents an optimized culture method for Wharton’s Jelly-derived Mesenchymal Stem Cells (WJMSCs) using a serum and xeno-free system.
Scalable Production of Clinically Compliant Immunomodulatory Extracellular Vesicles from Wharton’s Jelly-Derived Mesenchymal Stem Cells for Translational Applications
A scalable method for isolating extracellular vesicles (EVs) using tangential flow filtration and size exclusion chromatography. The EVs are characterized for immunomodulatory properties, cytokine content, and clinical compliance, highlighting their potential for translational and therapeutic use.
Our Scientists' Contributions
Peer-reviewed works by our team members, reflecting over 30 years of combined expertise in stem cell and regenerative science
Adipose MSCs Suppress MCF7 and MDA-MB-231 Breast Cancer Metastasis and EMT Pathways Leading to Dormancy via Exosomal-miRNAs Following Co-Culture Interaction
This paper discusses the interaction between Mesenchymal Stem Cells (MSCs) and cancer cells via exosomal miRNAs in determining the therapeutic role of MSC in treating breast cancer cells and relapse.
Probable impact of age and hypoxia on proliferation and microRNA expression profile of bone marrow-derived human mesenchymal stem cells
This study shows that MSC from old donors exhibited a reduction in proliferation rate and differentiation potential together with the accumulation of senescence features compared to that of young donors. However, MSC cultured under hypoxic condition showed enhanced self-renewing and proliferation capacity in both age groups as compared to normal condition.
Expression of odontogenic markers in stem cells from human exfoliated deciduous teeth treated with perivitelline fluid from horseshoe crab
Stem cells from human exfoliated deciduous teeth (SHED) makes an ideal source for mesenchymal stem cells (MSCs) for cell-based regenerative therapies due to their ability to differentiate into wide range of cells lineages. Previous studies have shown the potential of perivitelline fluid (PVF) to act as a supplement material in enhancing proliferation of cells and promoting the generation of certain organs due to its high primitive protein content.
Bio-Engineered Meniscus for Tissue Engineering
Exploring tissue engineering approaches to meniscal repair — including decellularized ECM scaffolds, stem cells, and growth factors — as alternatives to conventional surgical treatment for meniscal injuries.
The Role of Hibiscus sabdariffa L. (Roselle) in Maintenance of Ex Vivo Murine Bone Marrow-Derived Hematopoietic Stem Cells
Roselle extract helps protect and maintain stem cells in culture by boosting antioxidant defenses, reducing DNA damage, and improving survival, supporting safer and more effective stem cell therapies.
Effects Of N-Acetyl-Cysteine Supplementation On Ex-Vivo Clonogenicity And Oxidative Profile Of Lineage-Committed Hematopoietic Stem/Progenitor Cells
Hematopoietic stem and progenitor cells (HSPCs) are exposed to oxidative damage acquired during ex vivo expansion which affects their therapeutic potency. This reseach studies the effects of N-Acetyl-Cysteine (NAC) supplementation in preventing HSPSCs damage.
Off-the-Shelf Implant to Bridge a Urethral Defect: Multicenter 8-Year Journey From Bench to Bed
This research investigates the engineering of an acellular collagen mesh as a cost-effective, off-the-shelf alternative to tissue grafts for urethral reconstruction, demonstrating successful repair in animal models and early clinical trials.
Research Collaboration
Let's Advance Science Together
We actively welcome partnerships with academic institutions, clinical research organisations, biotech companies, and healthcare innovators who share our passion for exosome-based regenerative medicine.